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Article

A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progression.

Genetics - 1 Aug 2007

Barbosa Vitor, Kimm Naomi, Lehmann Ruth

Abstract excerpt

Meiotic checkpoints monitor chromosome status to ensure correct homologous recombination, genomic integrity, and chromosome segregation. In Drosophila, the persistent presence of double-strand DNA breaks (DSB) activates the ATR/Mei-41 checkpoint, delays progression through meiosis, and causes defects in DNA condensation of the oocyte nucleus, the karyosome. Checkpoint activation has also been linked to decreased...

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Identifiers

PMID: 17507684
DOI: 10.1534/genetics.106.069575
PMCID: PMC1950606

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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