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Article

Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.

Molecular and cellular biology - 1 Feb 2001

Oishi I, Iwai K, Kagohashi Y, Fujimoto H, Kariya K, Kataoka T, Sawa H, Okano H, Otani H, Yamamura H, Minami Y

Abstract excerpt

Although chromosomal segregation at meiosis I is the critical process for genetic reassortment and inheritance, little is known about molecules involved in this process in metazoa. Here we show by utilizing double-stranded RNA (dsRNA)-mediated genetic interference that novel protein kinases (Ce-CDS-1 and Ce-CDS-2) related to Cds1 (Chk2) play an essential role in meiotic recombination in Caenorhabditis elegans....

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Identifiers

PMID: 11158318
DOI: 10.1128/MCB.21.4.1329-1335.2001
PMCID: PMC99585

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