Article
Duplication of cyb-3 (cyclin B3) suppresses sterility in the absence of mdf-1/MAD1 spindle assembly checkpoint component in Caenorhabditis elegans.
Cell cycle (Georgetown, Tex.) - 15 Dec 2010
Tarailo-Graovac Maja, Wang Jun, Tu Domena, Baillie David L, Rose Ann M, Chen Nansheng
Abstract excerpt
mdf-1/MAD1 is a conserved spindle assembly checkpoint component that is essential for the survival of Caenorhabditis elegans. Previously, using a dog-1(gk10)/FANCJ mutator strain, we have isolated a suppressor of mdf-1(gk2) sterility. This suppressor, named such-4, was demonstrated to be a tandem duplication that contained 62 putative protein coding genes. We apply here the recently developed Mos1-mediated...
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