Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker.

Genes, chromosomes & cancer - 1 Jan 2016

Stengel Anna, Kern Wolfgang, Zenger Melanie, Perglerová Karolína, Schnittger Susanne, Haferlach Torsten, Haferlach Claudia

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is a rare post-thymic T-cell neoplasm with aggressive clinical course and short overall survival. So far, due to the rareness of this disease, genetic data are available only from individual cases or small cohorts. In our study, we aimed at performing a comprehensive cytogenetic and molecular genetic characterization of T-PLL comprising the largest cohort of patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Genetic Variation

Share to Janus Kinase 3

Share to Prognosis

Share to Sequence Analysis, DNA

Share to Survival Analysis

Source

Identifiers

PMID: 26493028
DOI: 10.1002/gcc.22313

Genes

JAK3
ATM
BCOR
JAK1
MTCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker.PMID 26493028Read ↗

Current understandings on T-cell prolymphocytic leukemia and its association with TCL1 proto-oncogeneSemantic proximity Read ↗

Mature T-cell Leukemia Primarily Involving Blood and Bone Marrow without TCL1 or MTCP1 Rearrangement: A Subtype of T-Prolymphocytic Leukemia or a Distinct Entity?Semantic proximity Read ↗

T-Cell Prolymphocytic Leukemia: Diagnosis, Pathogenesis, and Treatment.Semantic proximity Read ↗

T-cell prolymphocytic leukemia frequently shows cutaneous involvement and is associated with gains of MYC, loss of ATM, and TCL1A rearrangement.Semantic proximity Read ↗

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53Semantic proximity Read ↗

JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLLSemantic proximity Read ↗

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.Semantic proximity Read ↗

Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.Semantic proximity Read ↗

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.Semantic proximity Read ↗

An update on genetic aberrations in T-cell neoplasms.Semantic proximity Read ↗

Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemiaSemantic proximity Read ↗

Genetic landscape of T- and NK-cell post-transplant lymphoproliferative disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.