Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL

30 Sept 2022

Abstract excerpt

Upregulation of the proto-oncogene T-cell leukemia/lymphoma 1A (TCL1A) is causally implicated in various B-cell and T-cell malignancies. High-level TCL1A correlates with aggressive disease features and inferior clinical outcomes. However, the molecular and cell biological consequences of, particularly nuclear, TCL1A are not fully elucidated. We observed here in mouse models of subcellular site-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Cancer-related Molecular Pathways
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36179280
DOI: 10.1182/blood.2022015494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLLPMID 36179280Read ↗

The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1ASemantic proximity Read ↗

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.Semantic proximity Read ↗

DNA damage pathways and B-cell lymphomagenesis.Semantic proximity Read ↗

Translationally Controlled Tumor Protein Induces Mitotic Defects and Chromosome Missegregation in Hepatocellular Carcinoma DevelopmentSemantic proximity Read ↗

Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignanciesSemantic proximity Read ↗

Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)Semantic proximity Read ↗

Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.Semantic proximity Read ↗

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.Semantic proximity Read ↗

Lessons learned from the Eµ-TCL1 mouse model of CLLSemantic proximity Read ↗

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.Semantic proximity Read ↗

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.Semantic proximity Read ↗

Transient genomic instability drives tumorigenesis through accelerated clonal evolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.