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Article

Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.

Genes, chromosomes & cancer - 1 Apr 2014

Bergmann Anke K, Schneppenheim Sina, Seifert Marc, Betts Matthew J, Haake Andrea, Lopez Cristina, Maria Murga Penas Eva, Vater Inga, Jayne Sandrine, Dyer Martin J S, Schrappe Martin, Dührsen Ulrich, Ammerpohl Ole, Russell Robert B, Küppers Ralf, Dürig Jan, Siebert Reiner

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is an aggressive post-thymic T-cell malignancy characterized by the recurrent inv(14)(q11q32)/t(14;14)(q11;q32) or t(X;14)(q28;q11) leading to activation of either the TCL1 or MTCP1 gene, respectively. However, these primary genetic events are insufficient to drive leukemogenesis. Recently, activating mutations in JAK3 have been identified in other T-cell malignancies. Since...

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Source

Identifiers

PMID: 24446122
DOI: 10.1002/gcc.22141

Genes

JAK3
MTCP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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