Article
Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.
Genes, chromosomes & cancer - 1 Apr 2020
Patil Paurnima, Cieslak Agata, Bernhart Stephan H, Toprak Umut H, Wagener Rabea, López Cristina, Wiehle Laura, Bens Susanne, Altmüller Janine, Franitza Marek, Scholz Ingrid, Jayne Sandrine, Ahearne Matthew J, Scheffold Annika, Jebaraj Billy M C, Schneider Christof, Costa Dolors, Braun Till, Schrader Alexandra, Campo Elias, Dyer Martin J S, Nürnberg Peter, Dürig Jan, Johansson Patricia, Böttcher Sebastian, Schlesner Matthias, Herling Marco, Stilgenbauer Stephan, Macintyre Elizabeth, Siebert Reiner
Abstract excerpt
T-cell prolymphocytic leukemia (T-PLL) is an aggressive tumor with leukemic presentation of mature T-lymphocytes. Here, we aimed at characterizing the initial events in the molecular pathogenesis of T-PLL and particularly, at determining the point in T-cell differentiation when the hallmark oncogenic events, that is, inv(14)(q11q32)/t(14;14)(q11;q32) and t(X;14)(q28;q11) occur. To this end, we mined whole genome...
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