SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is an aggressive malignancy with a median survival of the patients of less than two years. Besides characteristic chromosomal translocations, frequent mutations affect the ATM gene, JAK/STAT pathway members, and epigenetic regulators. We here performed a targeted mutation analysis for 40 genes selected from a RNA sequencing of 10 T-PLL in a collection of 28 T-PLL, and an...

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• Aged
• Aged, 80 and over
• HERC2 gene
• SAMHD1 gene
• Mutation