Article
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Nature communications - 15 Feb 2018
Schrader A, Crispatzu G, Oberbeck S, Mayer P, Pützer S, von Jan J, Vasyutina E, Warner K, Weit N, Pflug N, Braun T, Andersson E I, Yadav B, Riabinska A, Maurer B, Ventura Ferreira M S, Beier F, Altmüller J, Lanasa M, Herling C D, Haferlach T, Stilgenbauer S, Hopfinger G, Peifer M, Brümmendorf T H, Nürnberg P, Elenitoba-Johnson K S J, Zha S, Hallek M, Moriggl R, Reinhardt H C, Stern M-H, Mustjoki S, Newrzela S, Frommolt P, Herling M
Abstract excerpt
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules,...
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