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Current understandings on T-cell prolymphocytic leukemia and its association with TCL1 proto-oncogene

1 Apr 2020

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is a rare mature T cell leukemia with aggressive clinical course, poor response to conventional therapies and high mortality rates. Classical cytogenetics and various genetic techniques have observed complex karyotypes and associated genes involved in the molecular pathogenesis of T-PLL, among which the proto-oncogene T-cell leukemia/lymphoma 1 (TCL1) as a hallmark of...

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PMID: 32247279
DOI: 10.1016/j.biopha.2020.110107

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