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Article

Transgenic Mice for MTCP1 Develop T-Cell Prolymphocytic Leukemia

15 Jul 1998

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature T-cell leukemia associated with chromosomal rearrangements implicating MTCP1 or TCL1 genes. These genes encode two homologous proteins, p13(MTCP1) and p14(TCL1), which share no similarity with other known protein. To determine the oncogenic role of MTCP1, mice transgenic for MTCP1 under the control of CD2 regulatory regions (CD2-p13 mice) were...

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PMID: 9657733
DOI: 10.1182/blood.v92.2.368

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