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Article

Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development.

Biochemical and biophysical research communications - 6 Apr 2007

Kamimura Kenya, Ohi Hiroyuki, Kubota Tomoyuki, Okazuka Kiyoshi, Yoshikai Yoshihiro, Wakabayashi Yu-ichi, Aoyagi Yutaka, Mishima Yukio, Kominami Ryo

Abstract excerpt

Recurrent chromosomal rearrangements at BCL11B are found in human hematopoietic malignancies mostly of T-cell origin. However, it is unclear how this disruption contributes to oncogenesis, because the majority of leukemias express BCL11B from an undisrupted allele. Here, we show that Bcl11b(+/-)p53(+/-) mice exhibited greater susceptibility to lymphomas than Bcl11b(+/+)p53(+/-) mice but most lymphomas retained...

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Identifiers

PMID: 17306224
DOI: 10.1016/j.bbrc.2007.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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