Article
Characterization of envelope glycoprotein mutants for human T-cell leukemia virus type 1 infectivity and immortalization.
Journal of virology - 1 Oct 2001
Tsukahara T, Wielgosz M M, Ratner L
Abstract excerpt
The human T-cell leukemia virus type 1 (HTLV-1) envelope protein is required for virus spread. This study further characterizes the role of the envelope protein in HTLV-1 immortalization. Viruses with single amino acid substitutions within the SU protein at residue 75, 81, 95, 101, 105, or 195 or with a C-terminal cytoplasmic domain truncation (CT), as well as an envelope-null (EN) virus, were generated within an...
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