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Article

An intronic sequence mutated in flexed-tail mice regulates splicing of Smad5.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2007

Hegde Shailaja, Lenox Laurie E, Lariviere Andrew, Porayette Prashanth, Perry John M, Yon Michele, Paulson Robert F

Abstract excerpt

Recent work has identified a growing body of evidence that subtle changes in noncoding sequences can result in significant pathology. These mutations, which would have been called silent polymorphisms in the past, affect gene transcription and mRNA splicing and lead to drastic changes in gene expression. Previous work from our lab has characterized the murine flexed-tail (f) mutation, which encodes Smad5, a...

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Source

Identifiers

PMID: 18060457
DOI: 10.1007/s00335-007-9074-9

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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