Hypoxia Regulates BMP4 Expression in the Murine Spleen during the Recovery from Acute Anemia

Abstract excerpt

BACKGROUND: Bone marrow erythropoiesis is primarily homeostatic, producing new erythrocytes at a constant rate. However at times of acute anemia, new erythrocytes must be rapidly produced much faster than bone marrow steady state erythropoiesis. At these times stress erythropoiesis predominates. Stress erythropoiesis occurs in the fetal liver during embryogenesis and in the adult spleen and liver. In adult mice,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer, Hypoxia, and Metabolism
• Share to Erythrocyte Function and Pathophysiology
• Share to TGF-β signaling in diseases