Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BMP4 and Madh5 regulate the erythroid response to acute anemia.

Blood - 1 Apr 2005

Lenox Laurie E, Perry John M, Paulson Robert F

Abstract excerpt

Acute anemia initiates a systemic response that results in the rapid mobilization and differentiation of erythroid progenitors in the adult spleen. The flexed-tail (f) mutant mice exhibit normal steady-state erythropoiesis but are unable to rapidly respond to acute erythropoietic stress. Here, we show that f/f mutant mice have a mutation in Madh5. Our analysis shows that BMP4/Madh5-dependent signaling, regulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythropoiesis
Share to Acute Disease
Share to Anemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Protein 4

Share to Bone Morphogenetic Proteins

Share to Erythroid Cells

Share to Hematopoietic Stem Cells

Share to Spleen

Source

Identifiers

PMID: 15591122
DOI: 10.1182/blood-2004-02-0703

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BMP4 and Madh5 regulate the erythroid response to acute anemia.PMID 15591122Read ↗

Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling.Semantic proximity Read ↗

Hypoxia Regulates BMP4 Expression in the Murine Spleen during the Recovery from Acute AnemiaSemantic proximity Read ↗

BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development.Semantic proximity Read ↗

An intronic sequence mutated in flexed-tail mice regulates splicing of Smad5.Semantic proximity Read ↗

Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish.Semantic proximity Read ↗

In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitorsSemantic proximity Read ↗

Vhl deletion in <i>Dmp1</i> -expressing cells alters MEP metabolism and promotes stress erythropoiesisSemantic proximity Read ↗

Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor functionSemantic proximity Read ↗

Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.Semantic proximity Read ↗

Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.Semantic proximity Read ↗

Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesisSemantic proximity Read ↗

A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.