Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice

31 Jul 2023

Abstract excerpt

ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in hematopoietic stem and progenitor cells (HSPCs), where it is required for adult hematopoiesis. Heterozygous pathogenic germline ETV6 variants are associated with thrombocytopenia 5 (T5), a poorly understood genetic condition resulting in thrombocytopenia and predisposition to hematologic malignancies. To elucidate how germline ETV6 variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37522715
DOI: 10.1182/bloodadvances.2022009313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in micePMID 37522715Read ↗

Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors.Semantic proximity Read ↗

The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers.Semantic proximity Read ↗

Germline ETV6 mutations and predisposition to hematological malignancies.Semantic proximity Read ↗

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemiaSemantic proximity Read ↗

ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes.Semantic proximity Read ↗

ETV6 in hematopoiesis and leukemia predispositionSemantic proximity Read ↗

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.Semantic proximity Read ↗

ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic LeukemiaSemantic proximity Read ↗

Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and ThrombocytopeniaSemantic proximity Read ↗

Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.Semantic proximity Read ↗

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.Semantic proximity Read ↗

T505A variant of ETV5 promotes proliferation of precursor B cells in a mouse model of acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.