Snrnp25 is a candidate for the peri-implantation lethal phenotype of the Hba deletions.

Abstract excerpt

Mutations in adult hemoglobin alpha genes in humans lead to blood disorders commonly known as α-thalassemia. In search of a mouse model for this disease, mutagenesis screens have identified several deletions that resemble these phenotypes. The Hbab2(th) deletion, in particular, replicates the characteristics of alpha-thalassemia minor in heterozygous mice but presents a homozygous embryonic lethal phenotype....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to alpha-Globins
• Share to alpha-Thalassemia