Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers.

doi:10.1093/carcin/bgq096

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Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers.

Carcinogenesis - 1 Jul 2010

Park Sungshim L, Bastani Delara, Goldstein Binh Y, Chang Shen-Chih, Cozen Wendy, Cai Lin, Cordon-Cardo Carlos, Ding Baoguo, Greenland Sander, He Na, Hussain Shehnaz K, Jiang Qingwu, Lee Yuan-Chin A, Liu Simin, Lu Ming-Lan, Mack Thomas M, Mao Jenny T, Morgenstern Hal, Mu Li-Na, Oh Sam S, Pantuck Allan, Papp Jeanette C, Rao Jianyu, Reuter Victor E, Tashkin Donald P, Wang Hua, You Nai-Chieh Y, Yu Shun-Zhang, Zhao Jin-Kou, Zhang Zuo-Feng

Abstract excerpt

Constituents of tobacco smoke can cause DNA double-strand breaks (DSBs), leading to tumorigenesis. The NBS1 gene product is a vital component in DSB detection and repair, thus genetic variations may influence cancer development. We examined the associations between NBS1 polymorphisms and haplotypes and newly incident smoking-related cancers in three case-control studies (Los Angeles: 611 lung and 601 upper...

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PMID: 20478923
DOI: 10.1093/carcin/bgq096
PMCID: PMC2893801

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