Article
Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome.
Movement disorders : official journal of the Movement Disorder Society - 15 Feb 2008
Winkelmann Juliane, Lichtner Peter, Schormair Barbara, Uhr Manfred, Hauk Stephanie, Stiasny-Kolster Karin, Trenkwalder Claudia, Paulus Walter, Peglau Ines, Eisensehr Ilonka, Illig Thomas, Wichmann H-Erich, Pfister Hildegard, Golic Jelena, Bettecken Thomas, Pütz Benno, Holsboer Florian, Meitinger Thomas, Müller-Myhsok Bertram
Abstract excerpt
Sixty percent of the patients with restless legs syndrome (RLS) report a positive family history. To date five loci have been mapped on chromosome 12q, 14q, 9p, 2q, and 20p (RLS1-5) but no gene has been identified so far. To identify genes related to RLS, we performed a three-stage association study (explorative study, replication study, high-density mapping) in two Caucasian RLS case-control samples of...
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