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Article

Ghrelin-induced hippocampal neurogenesis and enhancement of cognitive function are mediated independently of GH/IGF-1 axis: lessons from the spontaneous dwarf rats.

Endocrine journal - 1 Jan 2013

Li Endan, Kim Yumi, Kim Sehee, Park Seungjoon

Abstract excerpt

We recently have reported that ghrelin modulates adult hippocampal neurogenesis. However, there is a possibility that the action of ghrelin on hippocampal neurogenesis could be, in part, due to the ability of ghrelin to stimulate the GH/insulin-like growth factor (IGF)-1 axis, where both GH and IGF-1 infusions are known to increase hippocampal neurogenesis. To explore this possibility, we assessed the impact of...

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PMID: 23774069
DOI: 10.1507/endocrj.ej13-0045

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