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Article

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007

Yu Xiao, Sun Jin-Peng, He Yantao, Guo Xiaoling, Liu Sijiu, Zhou Bo, Hudmon Andy, Zhang Zhong-Yin

Abstract excerpt

The lymphoid-specific tyrosine phosphatase (Lyp) has generated enormous interest because a single-nucleotide polymorphism in the gene (PTPN22) encoding Lyp produces a gain-of-function mutant phosphatase that is associated with several autoimmune diseases, including type I diabetes, rheumatoid arthritis, Graves disease, and systemic lupus erythematosus. Thus, Lyp represents a potential target for a broad spectrum...

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Source

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Identifiers

PMID: 18056643
DOI: 10.1073/pnas.0706233104
PMCID: PMC2148373

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.PMID 18056643Read ↗

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LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.Semantic proximity Read ↗

Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains.Semantic proximity Read ↗

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Allele-specific inhibitors of protein tyrosine phosphatases.Semantic proximity Read ↗

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