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Article

Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W.

PloS one - 1 Jan 2012

Liu Jing, Chen Ming, Li Rong, Yang Fan, Shi Xuanren, Zhu Lichao, Wang Hong-Mei, Yao Wei, Liu Qiji, Meng Fan-Guo, Sun Jin-Peng, Pang Qi, Yu Xiao

Abstract excerpt

The Lymphoid specific tyrosine phosphatase (Lyp) has elicited tremendous research interest due to the high risk of its missense mutation R620W in a wide spectrum of autoimmune diseases. While initially characterized as a gain-of-function mutant, R620W was thought to lead to autoimmune diseases through loss-of-function in T cell signaling by a recent study. Here we investigate the biochemical characters and T cell...

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PMID: 22952725
DOI: 10.1371/journal.pone.0043631
PMCID: PMC3428364

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Source receipt: pubmed, retrieved 7 Sept 2026.

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