Article

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

2022-01-14

Abstract excerpt

The kinase Csk is the primary negative regulator of the Src-family kinases (SFKs, e.g., Lck, Fyn, Lyn, Hck, Fgr, Blk, Yes), phosphorylating a tyrosine on the SFK C-terminal tail that mediates autoinhibition. Csk also binds phosphatases, including PTPN12 (PTP-PEST) and immune-cell PTPN22 (LYP/Pep), which dephosphorylate the SFK activation loop to promote autoinhibition. Csk-binding proteins (e.g., CBP/PAG1) oligome...

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Literature Corpus work: c72d64d2-7505-514b-b117-cddd2edca81f
DOI: 10.1101/2022.01.13.475555

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