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Article

Target-specific control of lymphoid-specific protein tyrosine phosphatase (Lyp) activity.

Bioorganic & medicinal chemistry - 15 Jul 2010

Walton Zandra E, Bishop Anthony C

Abstract excerpt

Lymphoid-specific protein tyrosine phosphatase (Lyp), a member of the protein tyrosine phosphatase (PTP) superfamily of enzymes, is an important mediator of human-leukocyte signaling. Lyp has also emerged as a potential anti-autoimmune therapeutic target, owing to the association of a Lyp-activating mutation with an array of autoimmune disorders. Toward the goal of generating a selective inhibitor of Lyp activity...

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Identifiers

PMID: 20594861
DOI: 10.1016/j.bmc.2010.06.022
PMCID: PMC2915760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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