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Article

Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2002

Song Robert X-D, McPherson Robert A, Adam Liana, Bao Yongde, Shupnik Margaret, Kumar Rakesh, Santen Richard J

Abstract excerpt

E2 rapidly activates MAPK in breast cancer cells, and the mechanism for this effect has not been fully identified. Since growth factor-induced MAPK activation involves signaling via the adapter protein Shc (Src-homology and collagen homology) and its association with membrane receptors, we hypothesized that breast cancer cells utilize similar signaling mechanisms in response to E2. In the present study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11773443
DOI: 10.1210/mend.16.1.0748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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