Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

Molecular cancer therapeutics - 1 May 2007

Zwart Wilbert, Griekspoor Alexander, Rondaij Mariska, Verwoerd Desiree, Neefjes Jacques, Michalides Rob

Abstract excerpt

Anti-estrogen resistance is a major clinical problem in the treatment of breast cancer. In this study, fluorescence resonance energy transfer (FRET) analysis, a rapid and direct way to monitor conformational changes of estrogen receptor alpha (ERalpha) upon anti-estrogen binding, was used to characterize resistance to anti-estrogens. Nine different anti-estrogens all induced a rapid FRET response within minutes...

Topics

Join the communities discussing this publication.

Estradiol
Estrogen Antagonists
Estrogen Receptor alpha
Estrogens
Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17513601
DOI: 10.1158/1535-7163.MCT-06-0750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.PMID 17513601Read ↗

A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.Semantic proximity Read ↗

Novel biosensors for the detection of estrogen receptor ligands.Semantic proximity Read ↗

ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers.Semantic proximity Read ↗

Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens.Semantic proximity Read ↗

An antiestrogen-responsive estrogen receptor-alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen.Semantic proximity Read ↗

Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.Semantic proximity Read ↗

A highly efficient and sensitive screening method for trans-activation activity of estrogen receptors.Semantic proximity Read ↗

Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.Semantic proximity Read ↗

Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer*Semantic proximity Read ↗

Mutations of tyrosine 537 in the human estrogen receptor-alpha selectively alter the receptor's affinity for estradiol and the kinetics of the interaction.Semantic proximity Read ↗

Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: correlations with DNA and coregulator interactions and receptor conformational changes.Semantic proximity Read ↗

Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.