Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells

16 Jan 2017

Abstract excerpt

Human induced pluripotent stem (iPS) cells can differentiate into cells of all three germ layers, including hematopoietic stem cells and their progeny. Interferon regulatory factor 8 (IRF8) is a transcription factor, which acts in hematopoiesis as lineage determining factor for myeloid cells, including dendritic cells (DC). Autosomal recessive or dominant IRF8 mutations occurring in patients cause severe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28090699
DOI: 10.1002/stem.2565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS CellsPMID 28090699Read ↗

Robust temporal map of human <i>in vitro</i> myelopoiesis using single-cell genomicsSemantic proximity Read ↗

A gene silencing pipeline to interrogate human cDC1 and pDC development and functionsSemantic proximity Read ↗

Modeling blood diseases with human induced pluripotent stem cellsSemantic proximity Read ↗

Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitorsSemantic proximity Read ↗

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and functionSemantic proximity Read ↗

Efficient generation of human dendritic cells from iPSC by introducing a feeder-free expansion step for hematopoietic progenitorsSemantic proximity Read ↗

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation.Semantic proximity Read ↗

Hematopoietic defects and iPSC disease modeling: lessons learned.Semantic proximity Read ↗

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.Semantic proximity Read ↗

Modeling primitive and definitive erythropoiesis with induced pluripotent stem cellsSemantic proximity Read ↗

The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function.Semantic proximity Read ↗

Genetic programming of macrophages generates an in vitro model for the human erythroid island nicheSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.