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Article

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

30 Mar 2021

Abstract excerpt

The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cells and is an important player in numerous retinal diseases. Gene manipulation in mice using the Cre-LoxP system is an invaluable tool for studying the genetic basis of these retinal diseases. However, existing RPE-targeted Cre mouse lines have critical limitations that restrict their reliability for studies of...

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PMID: 33784255
DOI: 10.1172/jci.insight.146604

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