Article
Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse.
The American journal of pathology - 1 May 2012
Thanos Aristomenis, Morizane Yuki, Murakami Yusuke, Giani Andrea, Mantopoulos Dimosthenis, Kayama Maki, Roh Mi In, Michaud Norman, Pawlyk Basil, Sandberg Michael, Young Lucy H, Miller Joan W, Vavvas Demetrios G
Abstract excerpt
The increasing popularity of the Cre/loxP recombination system has led to the generation of numerous transgenic mouse lines in which Cre recombinase is expressed under the control of organ- or cell-specific promoters. Alterations in retinal pigment epithelium (RPE), a multifunctional cell monolayer that separates the retinal photoreceptors from the choroid, are prevalent in the pathogenesis of a number of ocular...
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