Article

The <i>Dct</i> <sup>-/-</sup> mouse model to unravel retinogenesis misregulation in patients with albinism

2022-05-26

Abstract excerpt

We have recently identified DCT encoding dopachrome tautomerase (DCT) as the 8 th gene for oculocutaneous albinism (OCA). Patients with loss of function of DCT suffer from eye hypopigmentation and retinal dystrophy. Here we investigate the eye phenotype in Dct -/- mice. We show that their retinal pigmented epithelium (RPE) is severely hypopigmented from early stages contrasting with the darker melanocytic tiss...

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Literature Corpus work: c87950d3-7aca-5d0b-be62-e06ae3cdd6e6
DOI: 10.1101/2022.05.25.493436

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