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Article

Generation of<i>Cre</i>Transgenic Mice with Postnatal RPE-Specific Ocular Expression

7 Jan 2011

Abstract excerpt

PURPOSE: To generate and characterize a constitutively active, RPE-specific, cre-expressing transgenic mouse line. This line can be used to create RPE-specific knockouts by crossing with mice harboring loxP-flanked (floxed) genes. METHODS: A transgene construct was assembled with the BEST1 promoter driving cre expression. Transgenic mice were generated on a C57BL/6 background. Cre expression was assessed by...

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PMID: 21212186
DOI: 10.1167/iovs.10-6347

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