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Article

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice.

Human molecular genetics - 1 Jun 2006

Lloyd David J, Bohan Sandy, Gekakis Nicholas

Abstract excerpt

Prohormone convertase 1 (PC1) mutations lead to obesity in humans. However, Pc1 knockout mice do not become obese; in fact, they are runted due to a defect in growth-hormone releasing hormone processing, leading to the speculation that PC1 subserves different functions between mouse and human. Here, we report a novel allele of mouse Pc1 (N222D) that leads to obesity, abnormal proinsulin processing and multiple...

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Source

Identifiers

PMID: 16644867
DOI: 10.1093/hmg/ddl111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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