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Article

Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats.

The American journal of physiology - 1 Aug 1997

Levin B E, Dunn-Meynell A A, Balkan B, Keesey R E

Abstract excerpt

In outbred Sprague-Dawley rats, about one-half develop diet-induced obesity (DIO) on a diet relatively high in fat and energy (HE diet). The rest are diet resistant (DR), gaining weight and fat at the same rate as chow-fed controls. Here we selectively bred for high (DIO) and low (DR) weight gainers after 2 wk on HE diet. By the F5 generation, both male and female inbred DIO rats gained > 90% more weight than...

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Source

Identifiers

PMID: 9277561
DOI: 10.1152/ajpregu.1997.273.2.R725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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