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Article

Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats.

Obesity (Silver Spring, Md.) - 1 Feb 2010

Paulsen Sarah J, Jelsing Jacob, Madsen Andreas N, Hansen Gitte, Lykkegaard Kirsten, Larsen Leif K, Larsen Philip J, Levin Barry E, Vrang Niels

Abstract excerpt

The selectively bred diet-induced obese (DIO) and diet-resistant (DR) rats represent a polygenetic animal model mimicking most clinical variables characterizing the human metabolic syndrome. When fed a high-energy (HE) diet DIO rats develop visceral obesity, dyslipidemia, hyperinsulinemia, and insulin resistance but never frank diabetes. To improve our understanding of the underlying cause for the deteriorating...

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Identifiers

PMID: 19661956
DOI: 10.1038/oby.2009.245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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