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Article

Mechanisms of covalent self-assembly of the Azoarcus ribozyme from four fragment oligonucleotides.

Nucleic acids research - 1 Feb 2008

Draper Will E, Hayden Eric J, Lehman Niles

Abstract excerpt

RNA oligomers of length 40-60 nt can self-assemble into covalent versions of the Azoarcus group I intron ribozyme. This process requires a series of recombination reactions in which the internal guide sequence of a nascent catalytic complex makes specific interactions with a complement triplet, CAU, in the oligomers. However, if the CAU were mutated, promiscuous self-assembly may be possible, lessening the...

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Identifiers

PMID: 18048415
DOI: 10.1093/nar/gkm1055
PMCID: PMC2241849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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