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Article

Structure-function relationships of two closely related group IC3 intron ribozymes from Azoarcus and Synechococcus pre-tRNA.

Nucleic acids research - 1 Sept 2000

Ikawa Y, Naito D, Shiraishi H, Inoue T

Abstract excerpt

The two group IC3 pre-tRNA introns from Azoarcus and Synechococcus share very analogous secondary structures. They are small group I ribozymes that possess only two peripheral domains, P2 and P9. However, the 3'-splice site hydrolysis activity of the Synechococcus ribozyme critically depends on P2 whereas that of Azoarcus does not, indicating that the structure-function relationships of the two ribozymes are...

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Identifiers

PMID: 10954594
DOI: 10.1093/nar/28.17.3269
PMCID: PMC110692

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