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Article

Random removal of inserts from an RNA genome: selection against single-stranded RNA.

Journal of virology - 1 Feb 1996

Olsthoorn R C, van Duin J

Abstract excerpt

We have monitored the evolution of insertions in two MS2 RNA regions of known secondary structure where coding pressure is negligible or absent. Base changes and shortening of the inserts proceed until the excessive nucleotides can be accommodated in the original structure. The stems of hairpins can be dramatically extended but the loops cannot, revealing natural selection against single-stranded RNA. The 3' end...

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Identifiers

PMID: 8551609
DOI: 10.1128/JVI.70.2.729-736.1996
PMCID: PMC189873

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