Article
Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.
Carcinogenesis - 1 Feb 2008
Derks Sarah, Postma Cindy, Carvalho Beatriz, van den Bosch Sandra M, Moerkerk Peter T M, Herman James G, Weijenberg Matty P, de Bruïne Adriaan P, Meijer Gerrit A, van Engeland Manon
Abstract excerpt
Colorectal cancer (CRC) is a complex and heterogeneous disease in which genomic instability and DNA promoter methylation play important roles. The aim of this study was to investigate the relationship between chromosomal instability (CIN), microsatellite instability (MSI) and promoter methylation...
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