Article
Short-term selection for acute ethanol tolerance and sensitization from an F2 population derived from the high and low alcohol-sensitive selectively bred rat lines.
Alcohol (Fayetteville, N.Y.) - 1 Dec 2007
Radcliffe Richard A, Bludeau Pequita, Deng Xin-Sheng, Erwin V Gene, Deitrich Richard A
Abstract excerpt
Previous studies have identified quantitative trait loci (QTL) in the inbred high and low alcohol-sensitive rat (IHAS1 and ILAS1) strains. The original development of the strains involved selection for ethanol sensitivity based on duration of the loss of the righting reflex (LORR) after a standard dose of ethanol. This paper confirms some of these QTL using a short-term selection procedure based on the difference...
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