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Article

Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice.

Psychopharmacology - 1 May 2009

Hitzemann R, Edmunds S, Wu W, Malmanger B, Walter N, Belknap J, Darakjian P, McWeeney S

Abstract excerpt

RATIONALE: Previous studies have suggested that there is an inverse genetic relationship between ethanol consumption (two-bottle choice, continuous access) and ethanol withdrawal (e.g., Metten et al., Behav Brain Res 95:113-122, 1998a). OBJECTIVES: The current study used short-term selective breeding from heterogeneous stock (HS) animals to examine this relationship. The primary goal of the current study was to...

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Identifiers

PMID: 19052728
DOI: 10.1007/s00213-008-1418-y
PMCID: PMC5851459

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