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Article

Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate.

Molecular microbiology - 1 Jan 2008

Touzé Thierry, Tran An X, Hankins Jessica V, Mengin-Lecreulx Dominique, Trent M Stephen

Abstract excerpt

One-third of the lipid A found in the Escherichia coli outer membrane contains an unsubstituted diphosphate unit at position 1 (lipid A 1-diphosphate). We now report an inner membrane enzyme, LpxT (YeiU), which specifically transfers a phosphate group to lipid A, forming the 1-diphosphate species. (32)P-labelled lipid A obtained from lpxT mutants do not produce lipid A 1-diphosphate. In vitro assays with...

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Identifiers

PMID: 18047581
DOI: 10.1111/j.1365-2958.2007.06044.x
PMCID: PMC2229476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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