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Article

Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A.

The Journal of biological chemistry - 31 Dec 2004

Tran An X, Karbarz Mark J, Wang Xiaoyuan, Raetz Christian R H, McGrath Sara C, Cotter Robert J, Trent M Stephen

Abstract excerpt

Pathogenic bacteria modify the lipid A portion of their lipopolysaccharide to help evade the host innate immune response. Modification of the negatively charged phosphate groups of lipid A aids in resistance to cationic antimicrobial peptides targeting the bacterial cell surface. The lipid A of Helicobacter pylori contains a phosphoethanolamine (pEtN) unit directly linked to the 1-position of the disaccharide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15489235
DOI: 10.1074/jbc.M406480200
PMCID: PMC2552395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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