Article
Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity.
Molecular microbiology - 1 Mar 2014
Rubin Erica J, O'Brien John P, Ivanov Petko L, Brodbelt Jennifer S, Trent M Stephen
Abstract excerpt
Most Gram-negative organisms produce lipopolysaccharide (LPS), a complex macromolecule anchored to the bacterial membrane by the lipid A moiety. Lipid A is synthesized via the Raetz pathway, a conserved nine-step enzymatic process first characterized in Escherichia coli. The Epsilonproteobacterium Helicobacter pylori uses the Raetz pathway to synthesize lipid A; however, only eight of nine enzymes in the pathway...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.