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Article

Amino acid substitution at the dimeric interface of human manganese superoxide dismutase.

The Journal of biological chemistry - 13 Feb 2004

Hearn Amy S, Fan Li, Lepock James R, Luba James P, Greenleaf William B, Cabelli Diane E, Tainer John A, Nick Harry S, Silverman David N

Abstract excerpt

The side chains of His30 and Tyr166 from adjacent subunits in the homotetramer human manganese superoxide dismutase (Mn-SOD) form a hydrogen bond across the dimer interface and participate in a hydrogen-bonded network that extends to the active site. Compared with wild-type Mn-SOD, the site-specific mutants H30N, Y166F, and the corresponding double mutant showed 10-fold decreases in steady-state constants for...

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Identifiers

PMID: 14638684
DOI: 10.1074/jbc.M311310200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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