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Article

Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast.

Free radical biology & medicine - 20 Feb 2018

Das Andrew B, Sadowska-Bartosz Izabela, Königstorfer Andreas, Kettle Anthony J, Winterbourn Christine C

Abstract excerpt

Ribonucleotide reductase (RNR) catalyses the rate limiting step of DNA synthesis utilising a mechanism that requires a tyrosyl radical. We have previously shown that superoxide can quench protein tyrosyl radicals in vitro, either by oxidative addition, or reduction of the radical to tyrosine. Here, we observe that Saccharomyces cerevisiae strains lacking either copper-zincSOD (SOD1) or manganese SOD (SOD2) had...

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Source

Identifiers

PMID: 29305896
DOI: 10.1016/j.freeradbiomed.2018.01.001

Genes

SOD1
SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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