Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular pathobiology of gastrointestinal stromal sarcomas.

Annual review of pathology - 1 Jan 2008

Corless Christopher L, Heinrich Michael C

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) form an interesting group of sarcomas whose unique pathobiology provides a model of how molecularly targeted therapeutics can have a major impact on patient welfare. Approximately 85% of GISTs are driven by oncogenic mutations in either of two receptor tyrosine kinases: KIT or platelet-derived growth factor receptor alpha. We review the pivotal relationship between specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Gastrointestinal Stromal Tumors
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Piperazines

Share to Pyrroles

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Sarcoma

Share to Sunitinib

Source

Identifiers

PMID: 18039140
DOI: 10.1146/annurev.pathmechdis.3.121806.151538

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular pathobiology of gastrointestinal stromal sarcomas.PMID 18039140Read ↗

Gastrointestinal stromal tumors (GISTs): from science to targeted therapy.Semantic proximity Read ↗

Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine.Semantic proximity Read ↗

The molecular pathogenesis of gastrointestinal stromal tumors.Semantic proximity Read ↗

Molecular basis and management of gastrointestinal stromal tumors.Semantic proximity Read ↗

Translational insights into gastrointestinal stromal tumor and current clinical advances.Semantic proximity Read ↗

Gastrointestinal stromal tumor: advances in diagnosis and management.Semantic proximity Read ↗

Gastrointestinal stromal tumors.Semantic proximity Read ↗

Gastrointestinal stromal tumors: molecular markers and genetic subtypes.Semantic proximity Read ↗

Gastrointestinal stromal tumours: an update.Semantic proximity Read ↗

Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors.Semantic proximity Read ↗

New treatment strategies for advanced-stage gastrointestinal stromal tumours.Semantic proximity Read ↗

Gastrointestinal stromal tumor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.