Article
Translational insights into gastrointestinal stromal tumor and current clinical advances.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2018
Hemming M L, Heinrich M C, Bauer S, George S
Abstract excerpt
Gastrointestinal stromal tumor (GIST) is the most common soft tissue sarcoma of the gastrointestinal tract and, in the vast majority of cases, is characterized by activating mutations in KIT or, less commonly, PDGFRA. Mutations in these type III receptor tyrosine kinases (RTKs) account for over 85% of GIST cases, and the majority of KIT primary mutations respond to treatment with the tyrosine kinase inhibitor...
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