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Article

Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors.

International journal of molecular sciences - 23 Mar 2023

Masucci Maria Teresa, Motti Maria Letizia, Minopoli Michele, Di Carluccio Gioconda, Carriero Maria Vincenza

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common malignant mesenchymal neoplasms of the gastrointestinal tract. The gold standard for the diagnosis of GISTs is morphologic analysis with an immunohistochemical evaluation plus genomic profiling to assess the mutational status of lesions. The majority of GISTs are driven by gain-of-function mutations in the proto-oncogene c-KIT encoding the tyrosine...

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Source

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Identifiers

PMID: 37046997
DOI: 10.3390/ijms24076026
PMCID: PMC10094678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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