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Article

Molecular basis and management of gastrointestinal stromal tumors.

World journal of gastroenterology - 14 Jun 2010

Bayraktar Ulas D, Bayraktar Soley, Rocha-Lima Caio M

Abstract excerpt

Molecularly targeted agents have dramatically impacted the management of several cancers. Targeting KIT has led to a new treatment paradigm in gastrointestinal stromal tumors (GISTs). KIT is a cell surface receptor with tyrosine kinases that, upon binding of its ligand, stem cell factor, activates various signaling pathways. Imatinib and sunitinib, both tyrosine kinase inhibitors directed to KIT, were approved...

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Source

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Identifiers

PMID: 20533592
DOI: 10.3748/wjg.v16.i22.2726
PMCID: PMC2883128

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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